Saturday, April 21, 2018

OF MICE, NUDE MICE, AND NANOTUBES


Our Fur-less Friends
Well, the poor devil on the left

Do you know what an athymic nude mouse is?  Well, it is a hairless mouse with no thymus, abundantly used in cancer research.  Seems it lacks killer T cells, hence cannot resist the transplantation of various human cancers.  By God, we owe an enormous debt of gratitude to mice!  When we finally do conquer cancer, we should build a monument on The Mall.  The principal occupant should be the person (or computer algorithm) that finally cracked the conundrum – but crouching at his/her/its feet should be a marble mouse!

Which brings me to the subject of this blog.  As you know, detecting OVCA early enough to snuff it out is difficult.  Hell, to all intents and purposes, it’s impossible.  Now comes along a group who have constructed a carbon nanotube which has the characteristic of changing its electromagnetic  properties in the presence of the protein  HE4.  As demonstrated by the Fred Hutch group I used to help, high concentrations of HE4 are a “tell” for OVCA.  Unfortunately, by the time HR4 concentrations in blood samples reach a detectable level the patient is in stage 3.  These miraculous nanotubes, if located near the fallopian tubes, can do much better – or so indicate the nude mice. 

So, good, I guess.  But before I get too excited, I’d like to know:
                How do you implant the damned thing?
                Will every female baby get “implanted” at, say, birth?
                How often will a woman have to be “monitored?
                And, obviously – how much will it cost?


No comments:

Post a Comment