Tuesday, October 27, 2020

A VERY PROMISING NEW TOOL


           AN EXTRA FANCY DINNER IN CAIRO

Until very recently the only weapons available to combat cancer were surgery, chemotherapy, radiation – and, I suppose – prayer.  Radiation could be quite effective under a few circumstances; implanting a little seed of radioactive material next to a prostate cancer, for instance.  However, under most conditions radiation therapy required shooting a destructive beam through healthy tissue to get at a localized cancer mass inside.  This led to nasty side effects in some cases, and was worth doing only if the cancer hadn’t spread.

Well, now, those tax dollars you cheerfully gave over to the National Cancer Institute have yielded what seems to me may be a very important breakthrough.  As the article cited below will explain, it now seems to be possible to attach a tiny but nasty bit of radioactive material to molecules engineered (by nature and/or man) to seek out and glom onto cancer cells, thereby killing them without doing collateral damage to healthy tissue.  Furthermore, these little killer blobs can search out metastases wherever they may hide!  Nice, huh?

Read the NCI blurb and, if necessary, make sure your oncologist has read it, too.

https://www.cancer.gov/news-events/cancer-currents-blog/2020/radiopharmaceuticals-cancer-radiation-therapy?cid=eb_govdel 

Saturday, October 24, 2020

MORE ON PARPi


                  on hurricane ridge, a long time ago

 

Another study showing the effectiveness of PARP inhibitors in prolonging life for OVCA victims.  Be sure your oncologist is up to speed.

https://www.wsmv.com/news/vanderbilt-oncologist-says-ovarian-cancer-drug-gives-the-gift-of-time/article_0ce69512-023f-11eb-8134-cf5a563ac21e.html 

 

Saturday, October 17, 2020

PROTEINS AGAINST OVCA


                          Linda selects gourds to decorate

                                         Probably about  2005

This is a serious piece describing research inching us toward a cure for HGSOC .  HGSOC (high-grade serous ovarian cancer) is one of the most common types of OC, and also the most deadly; only about 35% of women diagnosed with HGSOC survive for five years.  Linda had HGSOC; she died after only about 3 1/2 years.

I am not going to try to summarize this excellent essay; read it yourself – and perhaps take a little heart.  With smart people like this working hard we will whip this SOB yet! 

https://www.theguardian.com/science/2020/oct/17/curing-the-incurable-ovarian-cancer-max-perutz-science-writing-award-2020-winner 

 

Thursday, October 8, 2020

CRISPR ONCE AGAIN


            Linda showing off an experimental hair-do

                      She ditched it ten minutes later

I have written many times of CRISPR and its use in gene editing.  I have told you that it is perhaps the most exciting new wrinkle in medical biology in a long, long time.  Well, I was right: its co-discoverers have just been awarded the Nobel Prize in Chemistry.  Here is Dr. Collins to tell you all about it:

https://directorsblog.nih.gov/2020/10/08/discussing-the-long-arc-of-discovery-with-nihs-newest-nobelist/ 

Also included is an interesting dialog on hepatitis C.