Friday, September 13, 2013

FREE MEDICAL ADVICE (and worth every penny)


In our swanky Cairo hotel.
4 Star (but the toilet overflowed)
What I am about to do is probably ill advised.  I am about to give medical advice.    I am not a doctor, nor a nurse, and until about 18 months ago I actually did my very  best to avoid learning anything at all about health – on the grounds that something you never  think about won’t hurt you.  Stupid, yes, but perhaps understandable.  So, anyway, here goes.  FOR GOD’S SAKE GET A SECOND OPINION!
I have spent a good part of the last 18 months reading things about cancer in general and ovarian cancer in particular.  At times I’m lucky if I truly understand 20% of the stuff I study – but 20% of a great pile  of stuff amounts to something.  Here is what I think I know about preventing ovarian cancer.
Don’t be a woman of Ashkenazi Jewish extraction.
Ovulate as infrequently as nature and fate will allow.  This means:
                Start ovulating late.
                Start menopause early.
                Have babies
  Breast feed
                Use  the kind of birth control methods that prevent ovulation.
Don’t use talc.  
Don’t have mutations in your BRCA1/2 genes.
Don’t have mutations in any of quite a few other genes, most of which we don’t even know about yet.
              In other words, don’t be unlucky.
Don’t use hormone therapy, at least without having serious conversation with several doctors.

Don't gain too much weight
The group I try to help has a classification system for risk of ovarian cancer (ROC)
If you are an Ashkenazi Jewish woman, or have known BRCA mutations, you are in the High Risk category.
                If you have several first-degree relatives (mother, sisters) that have had ovarian OR  breast cancer you are in the Elevated Risk category
                Otherwise you are in the normal risk category, with less than a 3% lifetime chance of developing  OVCA.
So, what to do?
                Talk to a genetics counselor. 
                Try to find and join a clinical trial.  Easy if you live in a big city, hard otherwise.
If you are in either higher risk category you might consider the following.
                Have a risk-reduction procedure.  You might do this as a byproduct of some other surgery or, if you are of high risk, you might consider having it done on its own.  Some factors to consider:
                Most “ovarian” cancers originate in the fallopian tubes.  Removing your ovaries deprives your body of hormones, thus making menopause miserable (they tell me.)  Consider doing what is known as BSOR:  Bilateral Salpingectomy with Ovarian Retention.  “Salpingectomy” means removal of fallopian tubes.  BSOR is especially recommended for women in the High Risk category. 
                Of course, don’t do anything until you have had all the kids you want (or can afford.) 
Once again: for the love of Pete, don’t take my world for anything.  Get some advice from someone who is paid to know something.
On a personal note: my first great granddaughter is hovering on the brink of independent life.  Her mother has given up moose hunting until she arrives.  The scene is thick with excitement. 


15 comments:

  1. I think that is a good summary! I'm surprised to see that first degree relatives having had cancer puts you at an elevated risk but not relatives further removed. I guess it probably varies quite a bit and matters how many people in your family have been so unlucky.
    And yes, just waiting on Evelyn! Glad she didn't decide to join us on Friday the 13th but I'm getting pretty anxious to meet her

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    1. No, second and higher degree relatives do count, just not as much. The formula is quite complicated. The fact that you have a grandmother, a great grandmother, two great-aunts and an aunt who developed breast cancer certainly puts you in the elevated risk category. Your sisters too, obviously. Just stay vigilant, and get into any clinical trials available.

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  2. Hardly nobody has read this blog, You should - especially if you're female.

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  3. Thanks for the reminder. I've now read it again. Since I only have one first-degree relative (dear, dear Linda) with ovarian cancer, does that take me out of the high risk category? Of course another way to look at it is 50% of my close female relatives had ovarian cancer. I will remain vigilant. I don't even know if my fallopian tubes were removed! I need to find out.

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  4. I have blogged previously about the preventative value of aspirin. I have been looking into it a bit more, and I am convinced that -- you should ask your doctor if, as the ubiquitous TV drug adds always say, "aspirin is for you." Although I don't know exactly how it works (by reducing inflammation, but why does that help?) , I am sure that it does help - at least with some very common cancer types. The downside of course is that too much aspirin might eat a hole in the bottom of your stomach. Which is bad. Hence, talk to your doctor, and tell him that Dr. P.M. Rothwell of Oxford University sent you. If he scoffs, let me know and I'll send him the references.

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  5. So, I am trying to help out at the Hutch by proof-reading and editing some research proposals, and I found something worth passing along. if you re-read the main article here you will know what BSOR stands for: Bilateral Salpingectomy with Ovary Retention. In plane English, removal of the fallopian tubes while leaving the ovaries intact. Well, official bodies in both Canada and the U.K. recommend BSOR for high risk women as well as for anyone having a hysterectomy. It should surprise no one that the U.S. lags behind. Nevertheless, if you fall into either of those categories, talk to your medical person, and make sure that he/she know what he/she is talking about.

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  6. More on BSOR (see previous comment)If you are female and through having babies, talk to your doctor.

    http://www.healio.com/hematology-oncology/gynecologic-cancer/news/online/%7B55aa697e-8898-4e77-8df1-a24c89e950a3%7D/salpingectomy-may-reduce-risk-for-ovarian-cancer

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  7. And more on hormone replacement therapy. I am more than slightly tired of our medical experts trumpeting the results of some massive study or other, telling us to do, or not do, something, only to reverse course a few years later. Naively, perhaps, I would think that with all the biostatisticians pulling down fine salaries in medical fields, it would be possible to design experiments that yield results capable of standing the test of time. Apparently not. This is why we needl those skeptical Greek mathematicians. So, look at this:
    http://www.thehealthsite.com/news/contrary-to-earlier-reports-risk-of-ovarian-cancer-after-hrt-is-extremely-small/


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  8. More on this subject. Read it.

    https://bay172.mail.live.com/?tid=cmRUKPWknS5BGShgAhWtiMjA2&fid=flinbox

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  9. Here is another article about hormonal therapy and ovarian cancer. My take on the subject is: If you don't have it (OVCA) give th4e hormones a pass, but -- if you DO have it, talk to an oncologist about this new research.
    http://www.onclive.com/web-exclusives/adjuvant-hormonal-therapy-linked-to-improved-outcomes-in-ovarian-cancer

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  10. The word spreads slowly.
    BSOR. This stands for bilateral salpingectomy with ovary retention. BSOR is the recommended treatment (for women undergoing hysterectomy, for whatever reason). It reduces the risk of “ovarian” cancer, while minimizing hormonal difficulties during menopause. Despite the emphatic recommendation of the ACOG (American Congress of Oncologists and Gynecologists), this procedure is followed only 5.9% of the time. In teaching hospitals and cancer centers, however, the rate rises to as much as 72%. This underscores the need to get treatment at specialized, high-throughput facilities.
    http://www.clinicaloncology.com/Other-Solid-Tumors/Article/04-16/New-Strategies-Are-Proposed-br-For-Ovarian-Cancer-Treatment/35932


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  11. More on BSOR, Does your gynecologist know this?

    http://news.yale.edu/2016/01/21/sparing-ovaries-and-removing-fallopian-tubes-may-cut-cancer-risk-few-have-procedure

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  12. Yes, surgical removal of ovaries and fallopian tubes prevents ovarian cancer, but does it lengthen your lifespan over-all? Apparently not, if this article is to be believed.

    http://www.techtimes.com/articles/196627/20170215/ovary-removal-during-hysterectomy-increases-risks-of-heart-disease-cancer-and-premature-death-reveals-new-study.htm

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  13. In case you thought this stuff is simplr, read this:
    https://medicalxpress.com/news/2018-10-crosstalk-fallopian-tube-ovary-ovarian.html

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  14. More on the removal of fallopian tubes - when, why, and how

    https://www.contemporaryobgyn.net/acog-annual-meeting/dr-cass-salpingectomy-part-1

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