Thursday, June 6, 2019

OLAPARIB: Remember the name


Linda & family, Kalamazoo

Remember this name:  Olaparib.  Olaparib is a PARP inhibitor, one of several immunotherapy approaches to cancer therapy.  Lately it has been shown to be effective against ovarian cancer, both the kind involved with BRCA mutation, and wild-type BRCA occurrences.

 “Wild-type” in the curious language of medicine, most often merely means “normal”.  It arose from initial study of fruit flies: they would put a chunk of rotten fruit on the window-sill, then capture the inevitable fruit flies and put them in a bottle.  They were looking for mutants, recognized by having red eyes.  The rest were just “wild type”

Can you imagine a career spent looking at fruit flies under a microscope?  I’d almost rather be a dentist.

And, in the first paragraph, where I used the word effective, I really meant “effective”.  Olaparib prolongs remission in some cases, but in its present state is not a cure.


Olaparib is a product of AstroZenica, a Swedish-UK amalgam headquartered in Britain.  Its shares currently sell for about $39.  Do not regard that as investment advice.

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