Thursday, July 25, 2019

THE HUTCH HONORS FRED HUTCHINSON


Linda in Cuzco

You know what Fred Hutch is, right?  But do you know who the person Fred Hutchinson was?  Well, he was a baseball player; pitcher and manager for the Detroit Tigers until he died  of cancer in 1964.  His brother, a physician, started the Fred Hutchinson Cancer Research Center in his honor.  This is the centenary of Fred’s birth, so the Hutch has issued a special volume of their newsletter in his honor.  You can access it here:


Among several interesting articles is a description of using gold nanoparticles to deliver CRISPR gene-modification directly to the spot it’s needed.

Tuesday, July 23, 2019

ANOTHER NEW WEAPON?


Elsie, Linda, and Borrego flowers

Apparently ovarian and pancreatic cancers are similar in some respects:  they both are solid tumors that are difficult to detect early enough to enable successful treatment.  Thus it is potentially important that research performed in Texas may have found a new weapon to combat these tumors when they are full grown, so to speak. 
Most treatments tackle the tumor head-on.  This new approach works by killing off the tumor’s “support troops”.  In order to prosper, a solid tumor must have the proper “micro environment”.  Required in that micro environment are fibers for support, and vessels to supply nutrients.  Apparently the tumor secretes a protein that facilitates this: fibrosis and angiogenesis.  The Houston folks have created a monoclonal antibody that shuts this protein down.

Extensive testing is underway.  It might be ready for people sometime next year.

Wednesday, July 17, 2019

ANOTHER LONG MAGAZINE ARTICLE YOU OUGHT TO READ


LINDA, IN THERAPY, AT A QUILTING RETREAT

I have written about  Dr. Siddhartha Mukherjee numerous times.  He is the author of a tremendously valuable book about cancer, The Emperor of All Maladies, which I praised wholeheartedly, as well a later book, The Cell:  an intimate history, which I didn’t like nearly so well.  Mukherjee also writes magazine articles and appears on TV.  I find this remarkable, because – as I understand it – his “day job” is full-time cancer researcher.  I chided him about becoming spread way to soon in an earlier blog:  https://ljb-quiltcutie.blogspot.com/2018/06/god-damn-it-sidd-get-back-to-work.html.

Well, seems Sidd doesn’t read my stuff, because he has published yet another lengthy essay, this time in the New Yorker Magazine. 

So, about this article…  It’s long.  It’s easy to read.  It has lots of interesting information, much of which you probably already know.  I think it is a bit disorganized, but Sidd is a certified genius, so what do I know?  It starts out as a selective history of the development of cellular medicine, gives you a brief explanation of how CAR T therapy works, or does not work, then ends with a discussion of how we are going to pay for cures of the future.  And throughout Sidd, masterful writer that he is, keeps you hooked with human interest stuff.

Okay, I recommend that you undertake this article.  Sidd is super bright and well educated, so anything he writes is worth reading.  But, as I’ve expressed before – I wish he would put more of that intellectual energy into curing cancer.
Put on that white coat, Sidd!

Monday, July 15, 2019

A NEW WEAPON


Linda on top of the world

Many years ago I remember travelling through Hershey, PA, with my whole family.  I remember absolutely nothing about that trip – except the overwhelmingly chocolate odor of Hershey, and fields nearby.  I don’t know how anyone could have lived there – and got anything useful done.  Probably they have somehow scrubbed the gaseous chocolate by now, more’s the pity.  At any rate, very serious work goes on in Hersey, in the form of medical research – some of Penn State’s health labs are located there.  And they have churned out some very promising information about ovarian cancer.

It appears that there is a protein – isocitrate dehydrogenase 1, if you must know -  that is essential for division, and hence multiplication, of cancer cells.  Without it, cells enter a state of “senescence” – that is, they go to sleep and, we hope, never wake up!

  There is a drug already in existence that promotes this happy state.  The young folk at the Hershey lab are hot on its trail.  May their efforts be blessed!

https://news.psu.edu/story/580398/2019/07/11/research/targeting-key-protein-may-keep-ovarian-cancer-cells-spreading









Saturday, July 13, 2019

THE VEGAN BIBLE: A book review


Not Vegan
But good

I have labored over this book for over two weeks, and I want to give it a fair review.  It is an important book and should not be dismissed with a “Ewh!  Broccoli throw- away” retort.  Reluctantly, I am afraid, I must recommend this book to any of you who are dead serious about lifetime health.  At 86 I am not so fervid about a prolonged existence, but even I have modified my diet because of this book – a tiny bit.  So, here goes.

The document in question is entitled How Not to Die, a monumentally absurd concept on its very face.  What a needed subtitle might say is foods to eat that may – perhaps – reduce your risk of dying from various common ailments.  Die you must.  Dying early can be largely prevented, so say the authors.

The author is Michael Greger, M.D.  Dr. Greger is fully qualified in the medical field, but seems to earn his living through lectures and writing.  He is assisted by Gene Stone, an editor-writer-ghost writer who is a practicing, and extoling, adherent to the vegan lifestyle.  As you probably know, I am a firm believer in omnivorism.  Nevertheless, I found much in How Not to Die to be worth considering.  Read it yourself and make up your own mind.

Unlike authors of much dietary literature, Dr. Greger backs up his claims, recommendations, and inflammatory statements with scientific citations; the final 129 pages are “references cited”.  I checked quite a few; some are what you might call “grey literature”, but most are from reputable journals.  Thus, we need to take Dr. G seriously.  So what does he say?

Well, he recommends a totally plant-based diet; in other words, be an all-in vegan.  If you can’t avoid meat entirely, at least stay away from chicken and, surprisingly, many kinds of fish.  Shun milk and anything made from it, like cheese and ice-cream.  Don’t drink too much booze (well, maybe a little won’t hurt), and stay away from soft drinks as fervently as if they were bottles filled with Black Death.  Whenever possible, consume raw stuff in preference to products made from them; in other words, don’t drink V8 juice, rather eat the eight vegetables themselves. 

And, of course, get your exercise.

So.  I am prepared to concede that, had I subsisted on broccoli, blue berries, beans and kale all my life I might have been marginally healthier on average,  and might die a few years later. But would the ultimate total of contentment be higher?  I doubt it.

Our very distant sort-of simian ancestors almost certainly were arboreal, and probably ate a plant-based diet.  But, for some reason they eventually swung down from the trees and began to eat animals.  Why would they do that, especially if it was a step backwards in an evolutionary sense?  Well, for one thing, a dead animal represents a far more concentrated source of energy than a comparable volume of shoots and leaves.  But, I maintain, the main reason may have been that – the dead animal simply tasted a whole lot better!  And thus was born the omnivore! 

The sad fact is that I have never encountered a vegan dish that I truly liked.  Some are almost passable, and some are okay but a bit bland and boring.  A few I have fed to the crows.  Dr. Greger implies that a vegan diet will grow on you, given time.  That may be so – but I don’t have that much time!

All that said, this is a serious, well-researched book.  If you are concerned with diet you can do worse than to study it.
     

Wednesday, July 3, 2019

THE STRAIGHT SKINNY ON OVCA


Linda and I, hemispheres apart

This is an article that summarizes what I believe to be the State of the Art where current treatment of ovarian cancer is concerned.  Be warned:  it is hard slogging.  I have been reading this kind of stuff for about seven years; even so I had to murmur “Huh?” and re-read many times.  There is so much important content in this article that it would be foolhardy of me to attempt a summary.  Plow into it on your own; it will be good mental exercise at the very least.

Here are some acronyms and mystery phrases I had to look up:

VEGF:  Vascular epithelial growth factor.  Tumors have to sprout blood vessels in order to grow and prosper.  Bevacizumab (Avastin) is a weapon that targets VEGF.
PFS:  Progression-free survival; e.g., how long between remission and evidence that the damned thing is growing again.
HR:  Hazard ratio.  A statistical term, here relating the effectiveness of bevaczimab.  The lower, the better.  HR = 1 means no effect.
OS:  Overall survival. 
Paclitaxel, carboplatin, gemcitabine, etc.  Names of standard platinum-based chemo drugs
Pegylated:  Don’t bother; a cute organic chemistry term we can and should ignore.

So:  Give it a try.  It never hurts to try.